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\u4e00\u3001\u708e\u75c7\u6ce2\u53ca\u751f\u7cbe\u5c0f\u7ba1\u4e0e\u8840\u777e\u5c4f\u969c
\u777e\u4e38\u7684\u5b9e\u8d28\u7531\u5927\u91cf\u751f\u7cbe\u5c0f\u7ba1\u6784\u6210\uff0c\u7ba1\u58c1\u5185\u7684\u751f\u7cbe\u4e0a\u76ae\u662f\u7cbe\u5b50\u53d1\u751f\u7684\u573a\u6240\u3002\u8840\u777e\u5c4f\u969c\u7531\u652f\u6301\u7ec6\u80de\u95f4\u7684\u7d27\u5bc6\u8fde\u63a5\u5f62\u6210\uff0c\u5b83\u5c06\u751f\u7cbe\u7ec6\u80de\u4e0e\u8840\u6db2\u5faa\u73af\u9694\u79bb\uff0c\u7ef4\u6301\u514d\u75ab\u8c41\u514d\u73af\u5883\u3002\u5f53\u7ec6\u83cc\u3001\u75c5\u6bd2\uff08\u5982\u816e\u817a\u708e\u75c5\u6bd2\uff09\u6216\u5176\u4ed6\u75c5\u539f\u4f53\u7ecf\u8f93\u7cbe\u7ba1\u9006\u884c\u6216\u8840\u884c\u64ad\u6563\u81f3\u777e\u4e38\u65f6\uff0c\u4f1a\u5f15\u53d1\u95f4\u8d28\u6c34\u80bf\u3001\u767d\u7ec6\u80de\u6d78\u6da6\u3002\u708e\u75c7\u4ecb\u8d28\u5982\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-6\u7b49\u7684\u91ca\u653e\uff0c\u53ef\u76f4\u63a5\u635f\u4f24\u751f\u7cbe\u4e0a\u76ae\u7ec6\u80de\uff0c\u5e76\u7834\u574f\u8840\u777e\u5c4f\u969c\u7684\u5b8c\u6574\u6027\u3002\u4e00\u65e6\u5c4f\u969c\u53d7\u635f\uff0c\u81ea\u8eab\u514d\u75ab\u7ec6\u80de\u53ef\u80fd\u8bc6\u522b\u7cbe\u5b50\u6297\u539f\uff0c\u4ea7\u751f\u6297\u7cbe\u5b50\u6297\u4f53\uff0c\u8fdb\u4e00\u6b65\u5e72\u6270\u7cbe\u5b50\u53d1\u751f\u3002\u65e5\u672c\u4e00\u9879\u9488\u5bf9\u6025\u6027\u9644\u777e\u777e\u4e38\u708e\u60a3\u8005\u7684\u7cbe\u6db2\u5206\u6790\u7814\u7a76\uff08Sato et al., 2013\uff09\u53d1\u73b0\uff0c\u6025\u6027\u671f\u7cbe\u5b50\u6d53\u5ea6\u4e0e\u6d3b\u529b\u663e\u8457\u4e0b\u964d\uff0c\u4e14\u7cbe\u6d46\u4e2d\u767d\u7ec6\u80de\u4ecb\u7d20-8\u6c34\u5e73\u4e0e\u7cbe\u5b50DNA\u788e\u7247\u5316\u6307\u6570\u5448\u6b63\u76f8\u5173\uff0c\u63d0\u793a\u708e\u75c7\u7a0b\u5ea6\u4e0e\u751f\u7cbe\u635f\u4f24\u5b58\u5728\u91cf\u6548\u5173\u7cfb\u3002
\u4e8c\u3001\u5c40\u90e8\u6e29\u5ea6\u5347\u9ad8\u4e0e\u6c27\u5316\u5e94\u6fc0\u7684\u53e0\u52a0\u6548\u5e94
\u9634\u56ca\u7684\u6563\u70ed\u529f\u80fd\u7ef4\u6301\u777e\u4e38\u6e29\u5ea6\u4f4e\u4e8e\u6838\u5fc3\u4f53\u6e29\u7ea62-4\u2103\uff0c\u8fd9\u662f\u7cbe\u5b50\u6b63\u5e38\u53d1\u751f\u7684\u5fc5\u8981\u7269\u7406\u6761\u4ef6\u3002\u9644\u777e\u777e\u4e38\u708e\u65f6\uff0c\u5c40\u90e8\u8840\u6d41\u589e\u52a0\u3001\u7ec4\u7ec7\u5145\u8840\u53ca\u708e\u6027\u6e17\u51fa\uff0c\u4f1a\u5bfc\u81f4\u9634\u56ca\u76ae\u6e29\u5347\u9ad8\u4e14\u6563\u70ed\u53d7\u963b\u3002\u6301\u7eed\u7684\u9ad8\u6e29\u73af\u5883\u53ef\u76f4\u63a5\u6291\u5236\u751f\u7cbe\u7ec6\u80de\u7684\u6709\u4e1d\u5206\u88c2\u4e0e\u51cf\u6570\u5206\u88c2\uff0c\u8bf1\u5bfc\u751f\u7cbe\u7ec6\u80de\u51cb\u4ea1\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u6d3b\u5316\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5728\u6d88\u706d\u75c5\u539f\u4f53\u7684\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u5927\u91cf\u6d3b\u6027\u6c27\u7c07\uff0c\u5f53\u8d85\u8fc7\u7ec4\u7ec7\u81ea\u8eab\u6297\u6c27\u5316\u80fd\u529b\u65f6\uff0c\u5373\u5f62\u6210\u6c27\u5316\u5e94\u6fc0\u3002\u6d3b\u6027\u6c27\u53ef\u653b\u51fb\u7cbe\u5b50\u819c\u5bcc\u542b\u7684\u4e0d\u9971\u548c\u8102\u80aa\u9178\uff0c\u5f15\u8d77\u8102\u8d28\u8fc7\u6c27\u5316\uff0c\u9020\u6210\u7cbe\u5b50\u819c\u6d41\u52a8\u6027\u4e0b\u964d\u3001\u7ebf\u7c92\u4f53\u529f\u80fd\u5f02\u5e38\u4ee5\u53ca\u6838DNA\u65ad\u88c2\u3002\u6709\u7814\u7a76\u5bf9\u9644\u777e\u777e\u4e38\u708e\u60a3\u8005\u7684\u524d\u77bb\u6027\u89c2\u5bdf\u663e\u793a\uff0c\u5728\u53d1\u75c5\u540e4-6\u5468\u5185\uff0c\u7cbe\u6db2\u6d3b\u6027\u6c27\u6c34\u5e73\u4ecd\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u800c\u7cbe\u5b50\u5b58\u6d3b\u7387\u548c\u524d\u5411\u8fd0\u52a8\u7387\u5206\u522b\u964d\u4f4e\u7ea640%\u548c50%\uff0c\u90e8\u5206\u60a3\u8005\u51fa\u73b0\u5c11\u5f31\u7578\u7cbe\u5b50\u75c7\u7684\u6539\u53d8\u3002
\u4e09\u3001\u9644\u777e\u7ba1\u963b\u585e\u4e0e\u7cbe\u5b50\u6210\u719f\u8fd0\u8f93\u969c\u788d
\u9644\u777e\u662f\u4e00\u6761\u9ad8\u5ea6\u8fc2\u66f2\u7684\u5355\u6839\u7ba1\u9053\uff0c\u5206\u4e3a\u5934\u3001\u4f53\u3001\u5c3e\u4e09\u90e8\uff0c\u5176\u7ba1\u8154\u5fae\u73af\u5883\u53c2\u4e0e\u7cbe\u5b50\u83b7\u5f97\u8fd0\u52a8\u80fd\u529b\u548c\u53d7\u7cbe\u6f5c\u80fd\u7684\u6210\u719f\u8fc7\u7a0b\u3002\u708e\u75c7\u6e17\u51fa\u7269\u4e2d\u7684\u7ea4\u7ef4\u86cb\u767d\u539f\u53ef\u5728\u9644\u777e\u7ba1\u8154\u5185\u5f62\u6210\u7ea4\u7ef4\u6027\u7c98\u8fde\uff0c\u751a\u81f3\u53d1\u5c55\u6210\u9644\u777e\u7ba1\u7684\u8282\u6bb5\u6027\u6216\u5b8c\u5168\u6027\u6897\u963b\u3002\u8fd9\u79cd\u6897\u963b\u82e5\u53d1\u751f\u4e8e\u9644\u777e\u5c3e\u6216\u8f93\u7cbe\u7ba1\u8d77\u59cb\u90e8\uff0c\u7cbe\u5b50\u5c06\u65e0\u6cd5\u6392\u51fa\uff0c\u5bfc\u81f4\u6897\u963b\u6027\u65e0\u7cbe\u5b50\u75c7\u3002\u5373\u4f7f\u672a\u5b8c\u5168\u5835\u585e\uff0c\u9644\u777e\u4e0a\u76ae\u7ec6\u80de\u7684\u5206\u6ccc\u548c\u5438\u6536\u529f\u80fd\u5728\u708e\u75c7\u540e\u53ef\u80fd\u5931\u8c03\uff0c\u6539\u53d8\u4e86\u8089\u78b1\u3001\u553e\u6db2\u9178\u7b49\u6210\u719f\u56e0\u5b50\u7684\u6d53\u5ea6\uff0c\u9020\u6210\u7cbe\u5b50\u867d\u7136\u5728\u6570\u91cf\u4e0a\u53ef\u80fd\u901a\u8fc7\uff0c\u4f46\u529f\u80fd\u6210\u719f\u4e0d\u8db3\uff0c\u8868\u73b0\u4e3a\u7cbe\u5b50\u524d\u5411\u8fd0\u52a8\u7387\u4f4e\u4e0b\u548c\u9876\u4f53\u53cd\u5e94\u80fd\u529b\u7f3a\u9677\u3002\u6765\u81ea\u6b27\u6d32\u6ccc\u5c3f\u5916\u79d1\u5b66\u4f1a\u7684\u6307\u5357\u6027\u6587\u4ef6\u6307\u51fa\uff0c\u53cc\u4fa7\u9644\u777e\u777e\u4e38\u708e\u540e\u51fa\u73b0\u65e0\u7cbe\u5b50\u75c7\u7684\u75c5\u4f8b\u4e2d\uff0c\u7ea6\u6709\u4e00\u534a\u5728\u5f71\u50cf\u5b66\u6216\u624b\u672f\u63a2\u67e5\u4e2d\u53d1\u73b0\u9644\u777e\u5c3e\u90e8\u6897\u963b\uff0c\u4e14\u6897\u963b\u6bb5\u75c5\u7406\u68c0\u67e5\u53ef\u89c1\u975e\u7279\u5f02\u6027\u6162\u6027\u708e\u75c7\u6539\u53d8\u3002
\u56db\u3001\u6162\u6027\u8fc1\u5ef6\u4e0e\u7ea4\u7ef4\u5316\u91cd\u5851\u7684\u8fdc\u671f\u540e\u679c
\u6025\u6027\u9644\u777e\u777e\u4e38\u708e\u82e5\u672a\u5b8c\u5168\u6d88\u9000\uff0c\u53ef\u8f6c\u5f52\u4e3a\u6162\u6027\u708e\u75c7\uff0c\u5bfc\u81f4\u777e\u4e38\u95f4\u8d28\u7ea4\u7ef4\u5316\u548c\u751f\u7cbe\u5c0f\u7ba1\u57fa\u5e95\u819c\u589e\u539a\u3002\u7ea4\u7ef4\u5316\u7ec4\u7ec7\u53d6\u4ee3\u751f\u7cbe\u4e0a\u76ae\uff0c\u76f4\u63a5\u51cf\u5c11\u6709\u6548\u7cbe\u5b50\u53d1\u751f\u9762\u79ef\u3002\u777e\u4e38\u95f4\u8d28\u7ec6\u80de\uff08Leydig\u7ec6\u80de\uff09\u529f\u80fd\u4e5f\u53ef\u80fd\u53d7\u5f71\u54cd\uff0c\u96c4\u6fc0\u7d20\u5206\u6ccc\u4e0b\u964d\uff0c\u62bd\u8840\u68c0\u6d4b\u53ef\u89c1\u8840\u6e05\u777e\u916e\u6c34\u5e73\u4f4e\u4e8e\u540c\u9f84\u5065\u5eb7\u7537\u6027\u53c2\u8003\u8303\u56f4\u3002\u4f4e\u777e\u916e\u72b6\u6001\u53cd\u8fc7\u6765\u51cf\u5f31\u652f\u6301\u7ec6\u80de\u7684\u8425\u517b\u4f5c\u7528\uff0c\u5f62\u6210\u6076\u6027\u5faa\u73af\u3002\u4e00\u9879\u4e3a\u671f\u4e24\u5e74\u3001\u7eb3\u5165136\u4f8b\u5355\u4fa7\u6025\u6027\u9644\u777e\u777e\u4e38\u708e\u60a3\u8005\u7684\u968f\u8bbf\u7814\u7a76\uff08Rusz et al., 2012\uff09\u62a5\u544a\uff0c\u75ca\u6108\u540e\u4ecd\u6709\u7ea620%\u7684\u60a3\u8005\u60a3\u4fa7\u777e\u4e38\u4f53\u79ef\u7f29\u5c0f\u8d85\u8fc720%\uff0c\u4e14\u7cbe\u6db2\u603b\u7cbe\u5b50\u8ba1\u6570\u6062\u590d\u81f3\u6b63\u5e38\u4f4e\u503c\u4ee5\u4e0a\u6c34\u5e73\u7684\u6bd4\u4f8b\u4ec5\u4e3a68%\uff0c\u63d0\u793a\u7ea6\u4e09\u6210\u60a3\u8005\u4f1a\u9057\u7559\u4e0d\u540c\u7a0b\u5ea6\u7684\u751f\u7cbe\u529f\u80fd\u51cf\u9000\u3002\u53cc\u4fa7\u53d1\u75c5\u8005\u9884\u540e\u66f4\u5dee\uff0c\u53d1\u751f\u6301\u7eed\u6027\u5c11\u7cbe\u5b50\u75c7\u7684\u98ce\u9669\u5347\u81f345%\u5de6\u53f3\u3002
\u4e94\u3001\u53ef\u9006\u6027\u4e0e\u4fdd\u62a4\u56e0\u7d20\u7684\u8003\u91cf
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